About Organic Reactions

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Organic Reactions is a secondary reference which synthesizes the organic chemistry literature around particular chemical transformations. Each chapter of Organic Reactions is devoted to a particular organic chemical reaction, and chapters provide exhaustive coverage of literature work in the form of a tabular survey of known reactions. Mechanistic and experimental details, including the scope and limitations of each transformation, are also included.


Description of the Book Series

Organic Reactions is a comprehensive reference work that contains authoritative, critical reviews of many important synthetic reactions. Authors for these chapters are solicited by the board of editors from leading chemists worldwide. The publication process entails a thorough peer-review process, ensuring the high quality and attention to detail for which this series is noted. Organic Reactions chapters focus primarily on the preparative aspects of a given transformation. Particular attention is paid to substrate scope, reaction limitations, stereochemical aspects, effects of chemical structures, and the selection of experimental conditions. Detailed procedures illustrating the significant modifications of the chemical reaction are also included, along with comparisons to other methods to achieve a similar transformation. Every chapter contains a comprehensive compilation all of the published examples of the reaction organized in tables according to the structure of the starting material. Each reaction is presented with information about the reaction conditions, yield, products, and is fully referenced.

The aim of Organic Reactions since its initial publication in 1942 has been to assist organic chemists in the design of new experiments by providing "critical discussions of the more important synthetic reactions." Organic Reactions is unique in providing an authoritative discussion of the topic reaction accompanied by tables that organize all published examples of the reaction being reviewed. This combination of critical discussion and thorough coverage is responsible for the leading position this series occupies for scientists interested in the reactions of organic chemistry. An additional distinctive feature of this series is that it is assembled almost entirely through voluntary dedicated efforts of its authors, editors and assistants.

The Organic Reactions book series is owned and copyrighted by Organic Reactions, Inc. a not-for-profit, private operating foundation incorporated in the state of Illinois. The books are published by John Wiley and Sons, Inc. who also manage and maintain the Organic Reactions website.

History of the Series (PDF)

Roger Adams, editor-in-chief of Organic Reactions from 1942-1960

The Beginning

The reasons for starting Organic Reactions and the ways in which it was planned to accomplish its goals are well stated in the Introduction to the Series, which is included at the beginning of each volume.

The decision to undertake the preparation and presentation of "critical discussions of the more important (synthetic) reactions" was made at a meeting of the editors of Organic Syntheses and representatives of John Wiley & Sons during the Eighth National Organic Chemistry Symposium at St. Louis in December 1939. At that meeting the organizational setup was agreed upon, the operating procedures were roughed out, and the topics and authors were selected for Volume 1. These actions were formalized by the incorporation of Organic Reactions in Illinois on August 1, 1942, for educational and research purposes, with Roger Adams, Harold R. Snyder, Werner E. Bachmann, John R. Johnson, and Louis F. Fieser as directors, and by the appearance later that year of Volume 1. Roger Adams was elected president and served as President and Editor-in-Chief until he was succeeded in both positions by Arthur C. Cope in 1960 with the publication of Volume 11. He remained an active member of the Editorial Board until his death in 1971. Professor Cope in turn was succeeded in 1966 by Professor William G. Dauben who served from 1966-1984. Subsequent Editors-in-Chief and Presidents of the corporation are: Professor Andrew S. Kende (1984-1988), Professor Leo A. Paquette (1988-2000) Professor Larry E. Overman (2000-2007) and Professor Scott E. Denmark (2008-present). The close relationship of Organic Reactions to Organic Syntheses, Roger Adams, and John Wiley & Sons is obvious; the great value of that relationship is equally obvious to all who have been connected with the series as editors and authors.

Some Organic Reactions chapters are made into dedicated books, such as this chapter on the Stille reaction by Farina et al.

Operating Procedures

The editors chose the topics to be covered and the authors who would be asked to write the chapters. These decisions, together with discussions of work in progress, were the bases of an annual working dinner for the editors. Invitations to write chapters were extended by the Editor-in-Chief, and those who knew Roger Adams will not be surprised that few invitations were declined. Correspondence with authors and publishers between the annual meetings was handled by one of the editors who also served as secretary.

There was no formal rule on an editor's length of service; the informal understanding with the original board of five was that they would serve through the publication of five volumes.

Each draft manuscript when received was duplicated and copies were sent to the editors. Every editor read each draft manuscript for accuracy and completeness of the chemistry involved and for clarity and effectiveness of presentation. Comments on these matters were sent in writing by each editor to the Responsible Editor-an editor who had either volunteered or had been "volunteered" (army style) to follow the manuscript, with the aid of the Secretary and the Editor-in-Chief, through to publication or rejection.

The Responsible Editor summarized the comments tactfully and sent the summary to the author to enable him to take advantage of the comments in revising the manuscript. The revised manuscript was read by the Responsible Editor and, if it met with his approval and that of the Editor-in-Chief, was copy edited and sent to the publisher. If the revised manuscript was not considered satisfactory it was referred to the Editorial Board, which would recommend rejection, acceptance, additional revision, or assistance by a co-author or an editor. The number of rejections was small but the amount of work done by authors and editors was often considerable.

The publisher also copy edited each accepted manuscript and sent it along for composition. Galley proofs were read by all editors and their marked galleys sent to the Secretary who combined the corrections on a set of master galleys that served as the basis for page proofs. All page proofs were read by all editors. Finally, one editor prepared the index and checked the front material, which had been made up by the publisher. The authors, of course, also read galley and page proofs.

Contributing Authors

Waldemar Adam
Joe T. Adams
Homer Adkins
Nicolas Agenet
David J. Ager
Noel F. Albertson
George R. Allen, Jr.
Diego A. Alonso
S. J. Angyal
Evan G. Antoulinakis
Marcel Apparu
S. Archer
Siméon Arseniyadis
Corinne Aubert
Werner E. Bachmann
W. E. Bachmann
Donald R. Baer
Luca Banfi
Jérôme Baudoux
Ellen W. Baxter
André Beauchemin
Lyell C. Behr
E. J. Behrman
Ernst D. Bergmann
Ernst Berliner
Jean-François Biellmann
Arthur J. Birch
Hans-Ulrich Blaser
J. M. Blatchly
A. H. Blatt
F. F. Blicke
Eric Block
Steven H. Bloom
Jordan J. Bloomfield
James M. Bobbitt
Dominique Bonafoux
G. A. Boswell, Jr.
William W. Brand
James H. Brewster
Herbert C. Brown
Weldon G. Brown
Christian Brückner
Herman L. Bruson
Donald E. Bublitz
Johannes S. Buck
Simone Bufali
Olivier Buisine
Steven D. Burke
Lewis L. Butz
Dominique Cahard
Drury Caine
T. L. Cairns
Marvin Carmack
Nancy E. Carpenter
Erick M. Carreira
H. E. Carter
James Cason
Bertrand R. Castro
Guy Casy
A. Richard Chamberlin
Marc J. Chapdelaine
André B. Charette
Bang-Chi Chen
Chia-Chung Cheng
Engelbert Ciganek
Robin D. Clark
Pat N. Confalone
Arthur C. Cope
Elias J. Corey
Donald J. Cota
Cameron J. Cowden
Jack K. Crandall
David Crich
Michael T. Crimmins
R. David Crouch
Nathan N. Crounse
Guido H. Daub
Vinod Dave
M. L. Davies
Franklin A. Davis
Ottorino DeLucchi
Scott E. Denmark
R. W. Denny
DeLos F. DeTar
J. Dickhaut
Carl Djerassi
L. Guy Donaruma
Nathan L. Drake
Adrien S. DuBois
Jean-Bernard Ducep
Jacques Dunoguès
Ernest L. Eliel
William S. Emerson
Robert Engel
D. C. England
Rulin Fan
Vittorio Farina
Robert J. Ferrier
Alec Fettes
Louis F. Fieser
Ian Fleming
Karl Folkers
James L. Fry
Reynold C. Fuson
Kumar G. Gadamasetti
Vincent Gandon
Robert E. Gawley
T. A. Geissman
Walter J. Gensler
B. Giese
Henry Gilman
David Ginsburg
T. Göbel
Tutucorin R. Govindachari
Paul A. Grieco
David Grierson
Heinz W. Gschwend
Benjamin W. Gung
C. David Gutsche
Karl L. Habermas
Howard A. Hageman
Dennis G. Hall
Cliff S. Hamilton
K. E. Hamlin
W. E. Hanford
Robert M. Hanson
Thomas M. Harris
Constance M. Harris
J. F. Harris, Jr.
Walter H. Hartung
C. H. Hassall
Charles R. Hauser
Yoshihiro Hayakawa
Richard F. Heck
Geoffrey R. Heintzelman
Walter Z. Heldt
Albert L. Henne
John E. Hofferberth
Roger A. Hoffman
Connie M. Hoiness
H. L. Holmes
William J. Houlihan
Herbert O. House
Tomásˇ Hudlicky´
Milosˇ Hudlicky´
Boyd E. Hudson, Jr.
David L. Hughes
Edward M. Huie
Martin Hulce
Earl S. Huyser
John Hyatt
Michael J. Idacavage
Walter S. Ide
A. W. Ingersoll
Shinichi Itsuno
Ernest L. Jackson
Thomas L. Jacobs
Alam Jahangir
Kavitha Jakka
Roy A. Johnson
William S. Johnson
John R. Johnson
Todd K. Jones
Reuben G. Jones
Gurnos Jones
G. Jones
Margaret J. Jorgenson
Motomu Kanai
C. Oliver Kappe
Tsutomu Katsuki
Andrew S. Kende
Milton C. Kloetzel
Paul Knochel
Shu Kobayashi
Jay K. Kochi
B. Kopping
Nathan Kornblum
Gennady M. Kosolapoff
Eunice M. Kreider
L. I. Krimen
Venkat Krishnamurthy
Grant R. Krow
Heinrich Kuhlmann
K. J. Kulicke
Marshall Kulka
Toni M. Kutchan
Keith S. Kyler
Hugo Lachance
John F. Lane
Gerald L. Larson
Marlin T. Leffler
Michael A. Letavic
Daan van Leusen
B. L. Lim
J. T. Link
Bruce H. Lipshutz
R. Daniel Little
Frederick A. Luzzio
Adalbert Maercker
Barney J. Magerlein
Yogesh R. Mahajan
Max Malacria
Jaroslav Málek
Frank B. Mallory
Clelia W. Mallory
H. F. Manske
Zbigniew Marcinow
Christiane Marti
Victor S. Martin
William B. Martin
Elmore L. Martin
Mohammad R. Masjedizadeh
Stuart McCombie
S. M. McElvain
C. H. McKeever
Jim I. McLoughlin
John E. McMurry
F. W. McOmie
Ivona R. Meigh
Egbert W. Meijer
Gagik G. Melikyan
Nabyl Merbouh
Koichi Mikami
Joseph A. Miller
Nicolas Millot
Umberto Miotti
Tsuyoshi Mita
Giorgio Modena
Gary A. Molander
Maurice L. Moore
Jack F. Morgan
Robert M. Moriarty
John W. Morton, Jr.
Erich Mosettig
Ralph Mozingo
Teruaki Mukaiyama
Harold R. Nace
Wataru Nagata
Carmen Nájera
Takeshi Nakai
Eiichi Nakamura
Saiyid M. Naqvi
Ei-Ichi Negishi
Janice M. Nelke
Todd D. Nelson
Melvin S. Newman
A. Nickon
Arnold T. Nielsen
Mark C. Noe
Ryoji Noyori
Masaji Ohno
Iwao Ojima
Masami Otsuka
Larry E. Overman
Dennis C. Owsley
Raphael Pappo
Leo A. Paquette
William E. Parham
Stanley J. Parmerter
Daniel J. Pasto
Ian Paterson
George R. Pettit
Ragini Phadke
Robert R. Phillips
Adriana B. Pierini
F. Christopher Pigge
Stanley H. Pine
Harold W. Pinnick
Michael J. Porter
H. K. Porter
Gary H. Posner
Om Prakash
Charles C. Price
Peter W. Rabideau
Norman Rabjohn
Michael W. Rathke
N. Rebecca Raulins
Peter W. Raynolds
Josephine W. Reed
Hans J. Reich
Tracy L. Reinhold
Allen B. Reitz
Sara Jane Rhoads
Bruce Rickborn
James H. Rigby
Kenneth L. Rinehart, Jr.
W. C. Ripka
Renata Riva
John D. Roberts
Alain L. Rodriguez
Herman R. Rodriguez
Arthur Roe
Christian S. Rondestvedt, Jr.
Roberto Rossi
Carmen Ruh-Pohlenz
Anton W. Rytina
Chantu R. Saha-Möller
Ana N. Santiago
John C. Sauer
John P. Schaefer
Neil E. Schore
J. W. Schulenberg
Edward E. Schweizer
William J. Scott
R. M. Scribner
Peter H. Seeberger
Martin F. Semmelhack
Saumitra Sengupta
Suresh Sethna
Robert H. Shapiro
Clay M. Sharts
John C. Sheehan
Roger A. Sheldon
William A. Sheppard
Masakatsu Shibasaki
David A. Shirley
Ralph L. Shriner
H. E. Simmons
Robert Simonoff
John Skidmore
Franck Slowinski
Lee Irvin Smith
A. S. Smith
Roger Smithers
Sheri L. Snow
M. A. Spielman
Felix Spindler
Paul E. Spoerri
F. W. Stacey
Alexander Stadler
Stephen P. Stanforth
Hermann Stetter
W. S. Struve
C. M. Suter
Frederic W. Swamer
Daniel Swern
Kazuhiko Takai
D. Stanley Tarbell
J. K. Taylor
Richard T. Taylor
G. Thoma
Thomas T. Tidwell
David Todd
Oscar Touster
F. Trach
W. E. Truce
William E. Truce
Elmer R. Trumbull
Chung-Ying Tsai
Charles E. Tucker
C. W. Tullock
Maria Tzamarioudaki
Motokazu Uemura
Albert M. van Leusen
Eugene E. van Tamelen
E. Vedejs
Susan A. Vladuchick
Helmut Vorbrüggen
William S. Wadsworth, Jr.
Cheves Walling
Everett L. Wallis
Olof Wallquist
Chia-Lin J. Wang
E. W. Warnhoff
Marcey L. Waters
David S. Watt
Steven M. Weinreb
Arthur W. Weston
Wilson M. Whaley
A. L. Wilds
Richard H. Wiley
David H. Williamson
Stephen R. Wilson
C. V. Wilson
Donald E. Wolf
Hans Wolff
Susan Wollowitz
John L. Wood
William D. Wulff
Hans Wynberg
Shigeru Yamago
Shou-Jen Yan
Mitsuru Yoshioka
Harold E. Zaugg
Cong-Gui Zhao
Ping Zhou
Oleg A. Zubkov
George Zweifel

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